Isolated hapten-binding receptors of sensitized lymphocytes. II. Receptors from nylon wool-enriched rabbit T lymphocytes lack serological determinants of immunoglobulin constant domains but carry the A locus allotypic markers
نویسندگان
چکیده
Hapten-binding receptor material was isolated from sensitized rabbit lymphocytes by a method described previously for murine receptor material. The material was separated into a fraction expressing immunoglobulin determinants (anti-Ig+ fraction) and a fraction lacking known class and type-specific determinants of Ig constant domains (anti-Ig- fraction). We present evidence in support of the notion that--in analogy to the mouse system--the anti-Ig+ fraction is B-cell-derived, whereas the anti-Ig- fraction originates from T lymphocytes. Receptors of the anti-Ig- phenotype are found to express a locus allotypic determinants and, thus, appear to carry variable portions of immunoglobulin heavy chains.
منابع مشابه
ISOLATED HAPTEN-BINDING RECEPTORS OF SENSITIZED LYMPHOCYTES II. Receptors from Nylon Wool-Enriched Rabbit T Lymphocytes Lack Serological Determinants of Immunoglobulin Constant Domains but Carry the A Locus Allotypic Markers* BY ULRICH KRAWINKEL,$ MATTHIAS CRAMER, ROSE G. MAGE,
In the preceding paper I a class of hapten-binding lymphocyte receptor molecules was described which lack detectable serological determinants of conventional immunoglobufin constant domains but appear to carry heavy chain variable portions. These receptor molecules which we call the anti-lgfraction as well as receptor molecules expressing class-specific imunoglobulin determinants-the so-called ...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 146 شماره
صفحات -
تاریخ انتشار 1977